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Abstract
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Article Information:
Ethanol Extract of Carica papaya Seeds Induces Reversible Contraception in Adult Male Wistar Rats
Wilson O. Hamman, Sunday A. Musa, Daniel T. Ikyembe, Uduak E. Umana, Alexander B. Adelaiye, Andrew J. Nok and Samuel A. Ojo
Corresponding Author: Wilson Oliver Hamman
Submitted: 2011 August, 19
Accepted: 2011 September, 25
Published: 2011 November, 25 |
Abstract:
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The quest for the development of an ideal male contraceptive has led to the discovery of the
antifertility property of some species of C. papaya seed extracts. This study investigates the antifertility activity
and reversibility of ethanol extract of C. papaya seeds in sexually matured male Wistar rats. 30 adult males
and 60 female Wistar rats weighing between 180 and 220 g were used for the study. The male rats were
randomly divided into 3 groups of 10 each. Group I which served as control were orally administered distilled
water while groups II and III received 100 and 250 mg/kg/day of ethanol extract of C. papaya seeds
respectively for a period of 90 days. 5 males from each group were subjected to fertility test before they were
sacrificed to harvest the testes for histopathological analysis. The administration of the extract was discontinued
for another 90 days period and the remaining 5 males in each group were subjected to fertility test before they
were sacrificed to obtain the testes for histopathological analysis. The results showed normal pregnancy
outcome in the females paired with the control group, reduced and zero pregnancy outcome in the females
paired with the 100 and 250 mg/kg groups respectively after 90-day administration of the extract. After 90 days
of discontinued administration of extract, normal pregnancy outcome were recorded in both the control and
treated groups. The result of the histopathological analysis showed a moderate and highly depleted germinal
epithelium in the 100 and 250 mg/kg groups respectively after 90 day administration of the extract. The
germinal epithelium seen in both the control and the experimental groups were normal after 90 days
discontinued extract administration. The study concludes that ethanol extract of C. papaya seeds induces
reversible male contraception in Wistar rats.
Key words: C. papaya seeds, male wistar rats, reversible contraception, , , ,
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Cite this Reference:
Wilson O. Hamman, Sunday A. Musa, Daniel T. Ikyembe, Uduak E. Umana, Alexander B. Adelaiye, Andrew J. Nok and Samuel A. Ojo, . Ethanol Extract of Carica papaya Seeds Induces Reversible Contraception in Adult Male Wistar Rats. British Journal of Pharmacology and Toxicology, (5): 257-261.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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