Home           Contact us           FAQs           
 
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
    Abstract
2011 (Vol. 2, Issue: 5)
Article Information:

Ethanol Extract of Carica papaya Seeds Induces Reversible Contraception in Adult Male Wistar Rats

Wilson O. Hamman, Sunday A. Musa, Daniel T. Ikyembe, Uduak E. Umana, Alexander B. Adelaiye, Andrew J. Nok and Samuel A. Ojo
Corresponding Author:  Wilson Oliver Hamman 

Key words:  C. papaya seeds, male wistar rats, reversible contraception, , , ,
Vol. 2 , (5): 257-261
Submitted Accepted Published
2011 August, 19 2011 September, 25 2011 November, 25
Abstract:

The quest for the development of an ideal male contraceptive has led to the discovery of the antifertility property of some species of C. papaya seed extracts. This study investigates the antifertility activity and reversibility of ethanol extract of C. papaya seeds in sexually matured male Wistar rats. 30 adult males and 60 female Wistar rats weighing between 180 and 220 g were used for the study. The male rats were randomly divided into 3 groups of 10 each. Group I which served as control were orally administered distilled water while groups II and III received 100 and 250 mg/kg/day of ethanol extract of C. papaya seeds respectively for a period of 90 days. 5 males from each group were subjected to fertility test before they were sacrificed to harvest the testes for histopathological analysis. The administration of the extract was discontinued for another 90 days period and the remaining 5 males in each group were subjected to fertility test before they were sacrificed to obtain the testes for histopathological analysis. The results showed normal pregnancy outcome in the females paired with the control group, reduced and zero pregnancy outcome in the females paired with the 100 and 250 mg/kg groups respectively after 90-day administration of the extract. After 90 days of discontinued administration of extract, normal pregnancy outcome were recorded in both the control and treated groups. The result of the histopathological analysis showed a moderate and highly depleted germinal epithelium in the 100 and 250 mg/kg groups respectively after 90 day administration of the extract. The germinal epithelium seen in both the control and the experimental groups were normal after 90 days discontinued extract administration. The study concludes that ethanol extract of C. papaya seeds induces reversible male contraception in Wistar rats.
Abstract PDF HTML
  Cite this Reference:
Wilson O. Hamman, Sunday A. Musa, Daniel T. Ikyembe, Uduak E. Umana, Alexander B. Adelaiye, Andrew J. Nok and Samuel A. Ojo, 2011. Ethanol Extract of Carica papaya Seeds Induces Reversible Contraception in Adult Male Wistar Rats.  British Journal of Pharmacology and Toxicology, 2(5): 257-261.
    Advertise with us
 
ISSN (Online):  2044-2467
ISSN (Print):   2044-2459
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved