A review of some viral, neoplastic, environmental and nutritional diseases of African fish was carried out to educate fish famers on some likely challenges faced and their management processes n culture fisheries. The virus disease: Infectious Pancreatic Necrosis (IPN), Virus Hemorrhagic Septicemia, Carp Spring Viraemia (CSV) and Lymphocystis virus; Neoplastic fish diseases: Malignant Tumor and Benign Tumors; Disease of unknown etiology: Broken Head Disease and Open belly disease; Naturally occurring cases; Environmental fish diseases: Depletion of dissolved oxygen, temperature, exteme pH, mechanical trauma. Nutritional fish diseases: Deficiency in Essential Amino Acid (EAA), Feed proteins known to contain toxic amino acids and remedies for anti nutritional factors are areas reviewed.