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Abstract
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Article Information:
Protective Role of Water Extract of Unripe Pulp of Carica papaya (Fruit) Against a Potassium Bromate Induced Tissue Damage in Wistar Rats
S.J. Josiah, S.C.O. Nwangwu, A.A. Akintola, Abaja Vivian, G.O. Erifeta, A.A. Asuk and S.E. Uhunmwamgho
Corresponding Author: S.J. Josiah
Submitted: 2011 July, 02
Accepted: 2011 August, 16
Published: 2011 October, 25 |
Abstract:
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The aim of this study was to evaluate the protective role of water extract of unripe pulp of Carica
papya against potassium bromate induced tissue damage in wistar rats. Twenty (20) rats were grouped into five
groups of four rats each. Group A (base-line control), was administered 1 mL of 0.25 M sucrose solution. Group
B was not pretreated with the extract but induced with KBrO3. Group C and D were pretreated with 250 mg/kg
and 500 mg/kg body weight of the extract respectively. Tissue damage was induced in Group B, C, and D by
oral administration of 60mg/kg body weight of potassium bromate. The rats were sacrificed eight hours after
KBrO3 induction and, the liver, spleen, brain, kidney, heart and stomach were collected. The organ to body
weight ratio, total protein, amino acid and malondialdelhyde level were evaluated in the tissue. The result
showed a significant increase (p<0.05) in all these parameters in Group B when compared with Group A.
Except for the liver that increases in total amino acid and total protein level in Group C, the organ to body
weight ratio, total amino acid level, total protein level and malodialdehyde level of all the tissues investigated
decreases significantly (p<0.05) in Group C and D when compared with Group B. This suggests that the water
extract of unripe pulp of Carica papaya (fruit) has a protective role against tissue damage induced by KBrO3.
Key words: Carica papaya, free radicals, malondialdehyde, potassium bromate, , ,
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Cite this Reference:
S.J. Josiah, S.C.O. Nwangwu, A.A. Akintola, Abaja Vivian, G.O. Erifeta, A.A. Asuk and S.E. Uhunmwamgho, . Protective Role of Water Extract of Unripe Pulp of Carica papaya (Fruit) Against a Potassium Bromate Induced Tissue Damage in Wistar Rats. British Journal of Pharmacology and Toxicology, (4): 205-208.
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ISSN (Online): 2044-2467
ISSN (Print): 2044-2459 |
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