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2011 (Vol. 2, Issue: 3)
Article Information:

Determination of Nephrotoxicity and Hepatoxicity of Monosodium Glutamate (MSG) Consumption

H.M. Inuwa, V.O. Aina, Baba Gabi, I. Aim ola and Leehman Ja’afaru
Corresponding Author:  H.M. Inuwa 

Key words:  Adult wister rats, hepatoxicity, monosodium glutamate, nephrotoxicity, serum biochemistry carcinogenic, ,
Vol. 2 , (3): 148-153
Submitted Accepted Published
2011 May, 21 2011 July, 02 2011 August, 05

Investigations were conducted to determine the Nephrotoxicity and Hepatoxicity of Monosodium Glutamata (MSG). Graded doses of monosodium glutamate were administered orally to Adult Wister rats weighing between (160.7-238.6 g) for 28 days. Liver and Kidney function tests were carried out on the blood serum. Monosodium glutamate elicited an increase in body weight in an ascending fashion from group B to group D though not statistically significant (p>0.05) Biochemical parameters (Electrolytes, Urea, Creatinine, RBC, Cholesterol and Enzymes) were not seriously affected though there were increases in the concentration or levels of same of them. This shows that monosodium glutamate has hepatoxicity and nephrotoxicity tendencies especially when consumed at higher concentrations.
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  Cite this Reference:
H.M. Inuwa, V.O. Aina, Baba Gabi, I. Aim ola and Leehman Ja’afaru, 2011. Determination of Nephrotoxicity and Hepatoxicity of Monosodium Glutamate (MSG) Consumption.  British Journal of Pharmacology and Toxicology, 2(3): 148-153.
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ISSN (Online):  2044-2467
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