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    Abstract
2011 (Vol. 2, Issue: 3)
Article Information:

Combined Effect of Aqueous Extracts of Phyllathus amarus and Vitex doniana Stem Bark on Blood Glucose of Streptozotocin (STZ) Induced Diabetes Rats and Some Liver Biochemical Parameters

O.A. Owolabi, D.B. James, K.M. Anigo, G.W. Iormanger and I.I. Olaiya
Corresponding Author:  Dorcas B. James 

Key words:  Aqueous extracts, albio rats, diabetes, hepatoprotective, Phyllathus amarus, polytherapy, Vitex doniana
Vol. 2 , (3): 143-147
Submitted Accepted Published
2011 May, 30 2011 July, 18 2011 August, 05
Abstract:

The effects of aqueous extract of Phyllathus amarus and Vitex doniana stem bark on blood glucose of Streptozotocin (STZ) induced diabetes rats and some liver biochemical parameters were investigated. Study was conducted with 36 albino rats (wistar strain). Thirty- six rats (30 diabetic and 6 non-diabetic) were assigned into six groups of 6 rats each. Daily administration of the extracts for 21 days was done. Group 1 were the control animals, and group two diabetic control, while those of group 3, 4 and 5 were administered (100 mg/kg body weight extracts of Phyllanthus amarus, Vitex doniana and combination of the two respectively, group 6 was injected with insulin (5 units/kg) as a standard drug. Significantly (p<0.05) lower fasting blood glucose relative to their initial values at the end of treatment were observed for all treated group compared to normal and diabetic control. Similarly fasting blood glucose respectively decrease by 46.53, 74.46, 37.31 and 66.6% for Phyllanthus amarus, Vitex doniana, combination of Phyllanthus and Vitex doniana and insulin groups respectively relative to the diabetic control value of 525.5077.93 mg/dL. The extent of decrease of fasting blood glucose in the Vitex doniana extracts is significantly (p<0.05) higher than the other extracts treated groups. The extracts significantly (p<0.05) lowered the serum activities of marker enzymes; ALT, AST and ALP. There was positive significant (p<0.05) correlation between serum activities of marker enzymes and fasting serum glucose (R = 0.85 for ALT, R = 0.75 for AST and 0.68 for ALP). Result of total bilirubin and total protein shows that non-treated diabetic group was significantly (p<0.05) higher in total bilirubin compared with treated group. While non-treated diabetic group, showed significant (p<0.05) decreased in total protein compared with the normal and the treated groups. These results suggest that the use of aqueous extract of these plants and their combination in the treatment of diabetes produce a significant (p<0.05) antidiabetic and hepatoprotective effect.
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  Cite this Reference:
O.A. Owolabi, D.B. James, K.M. Anigo, G.W. Iormanger and I.I. Olaiya, 2011. Combined Effect of Aqueous Extracts of Phyllathus amarus and Vitex doniana Stem Bark on Blood Glucose of Streptozotocin (STZ) Induced Diabetes Rats and Some Liver Biochemical Parameters.  British Journal of Pharmacology and Toxicology, 2(3): 143-147.
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