Aqueous and ethanolic leaf extracts of Blighia sapida was assessed for som e lipid profile parameters in normal albino rats. Daily administration of the extracts (50 and 100 mg/kg body weight) for 21days showed that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglycerides and LDL-cholesterol in all the treated groups when compared with the control. While significantly (p<0.05) higher value was observed for the HDL-cholesterol of all the treated groups when compared with the control, this effect was observed as dose dependent for aqueous extract. For the atherogenic indices, there was a significant (p<0.05) increase in HDL-cholesterol/Total cholesterol ratio, while LDL-cholesterol/HDL-cholesterol and log (TG/HDLCH) ratio showed a significant (p<0.05) decrease in treated groups compared to the control group. These findings may be of clinical importance to individuals at risk of cardiovascular disease.