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    Abstract
2010 (Vol. 2, Issue: 4)
Article Information:

Changes in Lipid Profile of Aqueous and Ethanolic Extract of Blighia sapida in Rats

O.A. Owolabi, D.B. James, A.B. Ibrahim, O.F. Folorunsho, I. Bwalla and F. Akanta
Corresponding Author:  Dorcas B James 

Key words:  Aqueous extract, antherogenic indices, Bligha sapida, ethanolic extract, lipid profiles, ,
Vol. 2 , (4): Page No: 177-180
Submitted Accepted Published
2010 April, 16 2010 May, 04 2010 August, 30
Abstract:

Aqueous and ethanolic leaf extracts of Blighia sapida was assessed for som e lipid profile parameters in normal albino rats. Daily administration of the extracts (50 and 100 mg/kg body weight) for 21days showed that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglycerides and LDL-cholesterol in all the treated groups when compared with the control. While significantly (p<0.05) higher value was observed for the HDL-cholesterol of all the treated groups when compared with the control, this effect was observed as dose dependent for aqueous extract. For the atherogenic indices, there was a significant (p<0.05) increase in HDL-cholesterol/Total cholesterol ratio, while LDL-cholesterol/HDL-cholesterol and log (TG/HDLCH) ratio showed a significant (p<0.05) decrease in treated groups compared to the control group. These findings may be of clinical importance to individuals at risk of cardiovascular disease.
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  Cite this Reference:
O.A. Owolabi, D.B. James, A.B. Ibrahim, O.F. Folorunsho, I. Bwalla and F. Akanta, 2010. Changes in Lipid Profile of Aqueous and Ethanolic Extract of Blighia sapida in Rats.  Asian Journal of Medical Sciences, 2(4): Page No: 177-180.
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