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Abstract
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Article Information:
Study of the Effect of Hydro-Ethanolic Extract of Commiphora africana (Stem-bark) on Sleeping Time and Convulsion in Mice
I. Ezekiel, M.A. M abrouk, J.O. Ayo, A.D.T. Goji, A.O. Okpanachi, A. Mohammed and Y. Tanko
Corresponding Author: Ezekiel Iliya
Submitted: 2009 December, 08
Accepted: 2009 December, 14
Published: 2010 June, 25 |
Abstract:
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The hydro-ethanolic extract of Commiphora africana (Engl Rich A.) (stem-bark) was investigated
for sleeping time and anti-convulsive activity. The anti-onvulsant activity was studied using the
penylenetetrazole-induced (PTZ) seizures in ice.The sleeping time was studied using the diazepam-induced
sleep in mice. The results showed that the hydro-ethanolic (stem-bark) extract of Commiphora africana possess
significant (p<0.05) sleep activity. The total sleep tim e rose (p<0.01) from 38±0.71min in the control group to
61.8±1.07, 72±1.05 and 94.2±1.11min in the groups treated with the extract at the doses of 50, 100 and 200
mg/kg, respectively. The result showed that hydro-ethanolic (stem-bark) extract of Commiphora africana
possess significant (p<0.05) anti-convulsant activity.The extract significantly (p<0.05) prolonged the onset of
convulsion in the non-protected mice that were administered 100 and 200 mg/kg of the extract, which showed
about 60% protection in the mice. The results of the preliminary phytochemical screening of Commiphora
africana stem bark extract revealed the presence of flavonoids, tannin, anthraquinone, cardiac glycosides,
triterpenoids, saponins, alkaloids and reducing sugars. The LD50 was calculated as 471.2 mg/kg in mice. It was
concluded that the plant may be good in treatment of sleep disorders and may be beneficial in the management
of absence and tonic-clonic seizures.
Key words: Commiphora africana, convulsion, diazepam, phytochemical screening, sleeping time, ,
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Cite this Reference:
I. Ezekiel, M.A. M abrouk, J.O. Ayo, A.D.T. Goji, A.O. Okpanachi, A. Mohammed and Y. Tanko, . Study of the Effect of Hydro-Ethanolic Extract of Commiphora africana (Stem-bark) on Sleeping Time and Convulsion in Mice. Asian Journal of Medical Sciences, (3): Page No: 85-88.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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