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Abstract
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Article Information:
Histological Signs of Neurodegeneration in the Cerebrum of Rats Fed with Diet Containing Yaji: The Complex Nigerian Suya Meat Sauce
A.O. Nwaopara, C.I.P. Anibeze and F.C. Akpuaka
Corresponding Author: Nwaopara, Anthony Obioma
Submitted: 2009 November, 05
Accepted: 2009 November, 24
Published: 2010 January, 20 |
Abstract:
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The aim of this histological study is to determine the neurodegenerative changes that might be
associated with an indiscriminate consumption of a Nigerian meat sauce called Yaji, based on the fact that there
is evidence that some of its constituents have excitotoxic potentials. Eighteen weeks old white albino rats of
an average weight of 170 g were used for this study that lasted for two weeks. They were divided into eight
groups (A-H). Group A rats served as control and were fed with normal feed (growers mash) only, while groups
B-H served as the test groups and w ere fed with normal feed plus graded levels of Yaji (B, 10; C, 20; D, 30;
E, 40; F, 50; G, 60 and H, 70%). The stained brain tissue micrographs showed neurogenerative changes
(vacuolations, pyknosis and cavitations) in the cerebrum of the test rats irrespective of the dosage. Our findings
suggest that an excessive consumption Yaji is capable of inducing brain tissue damage and this is likely
dependent upon the concentration of those ingredients with excitotoxic potentials in a given measure of Yaji.
It is our opinion that there is a need to regulate the production and consumption of Yaji.
Key words: Brain, cerebrum, excitotoxicity, neurodegeneration, Suya, Yaji,
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Cite this Reference:
A.O. Nwaopara, C.I.P. Anibeze and F.C. Akpuaka, . Histological Signs of Neurodegeneration in the Cerebrum of Rats Fed with Diet Containing Yaji: The Complex Nigerian Suya Meat Sauce. Asian Journal of Medical Sciences, (1): Page No: 16-21.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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