Home           Contact us           FAQs           
 
   Journal Page   |   Aims & Scope   |   Author Guideline   |   Editorial Board   |   Search
    Abstract
2010 (Vol. 2, Issue: 1)
Article Information:

Streptozotocin-induced Hyperglycemia Produces Dark Neuron in CA3 Region of Hippocampus in Rats

S.H. Ahmadpour, Y. Sadeghi and H. Haghir
Corresponding Author:  Shahriar Ahmadpour 

Key words:  CA3, dark neuron, diabetes, rat, stereptozotocin, ,
Vol. 2 , (1): Page No: 11-15
Submitted Accepted Published
2009 September, 29 2009 November, 23 2010 January, 20
Abstract:

Dark neurons have been reported in many pathological conditions, such as epilepsy, ischemia and hypoglycemia. All these pathological conditions cause increased extracellular excitatory neurotransm itters like glutamate. Glutamate has been involved in dark neuron formation. Increased extracellular glutamate has been reported in hippocampus of diabetic state. We aimed to study the effect of streptozotocin-induced diabetes on dark neuron formation in CA3 region of diabetic rats. Diabetes was induced by a single intrape ritoneal (IP) injection of streptozotocin (STZ) at a dose of 60 mg/kg dissolved in saline. C ontrol Animals w ere injected w ith saline only. In the end of 8 weeks, the brains were removed and hippocampi studied by gallyas method and transmission electron microscopy. Dark neurons in CA3 region of STZ -induced diabetic group showed high darkly Stained somata and axons. Dark neurons also showed shrinkage and detachment from surrounding tissues. Ultastructurally injured neurons in CA3 region of diabetic rats showed dark and electron dense appearance, chromatin condensation, margination and clumping. Present results showed that STZ-induced diabetes produces dark neuron in CA3 pyramidal layer of diabetic rats after 8 weeks. The mode of death in dark neurons is apoptosis.
Abstract PDF HTML
  Cite this Reference:
S.H. Ahmadpour, Y. Sadeghi and H. Haghir, 2010. Streptozotocin-induced Hyperglycemia Produces Dark Neuron in CA3 Region of Hippocampus in Rats.  Asian Journal of Medical Sciences, 2(1): Page No: 11-15.
    Advertise with us
 
ISSN (Online):  2040-8773
ISSN (Print):   2040-8765
Submit Manuscript
   Current Information
   Sales & Services
   Contact Information
  Executive Managing Editor
  Email: admin@maxwellsci.com
  Publishing Editor
  Email: support@maxwellsci.com
  Account Manager
  Email: faisalm@maxwellsci.com
  Journal Editor
  Email: admin@maxwellsci.com
  Press Department
  Email: press@maxwellsci.com
Home  |  Contact us  |  About us  |  Privacy Policy
Copyright © 2009. MAXWELL Science Publication, a division of MAXWELLl Scientific Organization. All rights reserved