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Abstract
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Article Information:
Analgesic Properties of Methanolic Extract of Matricaria recutita in Rats in both Acute and Chronic Pains
Zohre Ganjali, Jasem Estakhr, Fereshteh Javadian, Abbas Heidari, Vahid Rostamian and Somayeh Dehghani
Corresponding Author: Jasem Estakhr
Submitted: June 28, 2012
Accepted: August 08, 2012
Published: August 08, 2012 |
Abstract:
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Matricaria recutita is an important medicinal plant belonging to the family of Asteraceae. It is a well
recognized plant in the traditional medicine and is used by people in rural areas. This study is aimed to evaluate the
anti-pain effects of methanolic extract of Matricaria recutita. The experiments were performed on 40 male wistar
rats weighting 190 to 200 g, which were divided into 5 groups, each consisting of 8 rats. To evaluate the analgesic
effects, the formalin induced pain-test was used. All animals were pre-treated with an oral dose of extracts (100,
200, 300 mg/kg). The control group received no drug and the witness group at only received distilled water. Results
of this study showed that methanolic extract of Matricaria recutita can significantly reduce the pain depending on
the dose in acute phase. However, in chronic phase, the high dose of the extract could reduce the pain. It seems that
flavonoids can probably reduce intracellular calcium through inhibiting of NMDA receptors. It also reduces
activities of nitric oxide synthase enzyme and calcium dependent phospholipids A2, which results in antinociceptive
effects.
Key words: Analgesia, Matricaria recutita, rat, , , ,
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Abstract
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Cite this Reference:
Zohre Ganjali, Jasem Estakhr, Fereshteh Javadian, Abbas Heidari, Vahid Rostamian and Somayeh Dehghani, . Analgesic Properties of Methanolic Extract of Matricaria recutita in Rats in both Acute and Chronic Pains. Asian Journal of Medical Sciences, (4): 152-155.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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