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Abstract
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Article Information:
Identifying Active Site Cavities of Brain Derived Neurotrophic Factor Involved in Type II Diabetes
G. Satyavani, R. Rajender, M. Lalitha, Allam Appa Rao and G.R. Sridhar
Corresponding Author: G. Satyavani
Submitted: 2011 August, 22
Accepted: 2011 October, 07
Published: 2012 February, 25 |
Abstract:
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Active site prediction of BDNF is done to identify the locations of ligand binding sites and to predict
functional similarities between cavities to estimate the locations of bound ligands. BDNF is a member of the
neurotrophin family of growth factors, which are related to the canonical "Nerve Growth Factor", NGF. BDNF
is a small dimeric protein which is abundantly and widely expressed in the adult mammalian brain. Various
studies have shown possible links between BDNF and conditions, such as Diabetes, depression, schizophrenia,
obsessive-compulsive disorder, Alzheimer's disease, Huntington's disease, Rett syndrome, and dementia, as
well as anorexia nervosa and bulimia nervosa. Active site of BDNF is obtained by using active site prediction
server. The cavity1 is identified as the cavity highest volume with the following amino acid sequence as the
active site RTCEDFAIVKYSQGWLN the cavity points are 5.312Ao, 26.603Ao, 20.190Ao and the cavity
volume is 1498 A3.
Key words: Active site, BDNF, cavities, interaction sites, type II Diabetes, ,
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Cite this Reference:
G. Satyavani, R. Rajender, M. Lalitha, Allam Appa Rao and G.R. Sridhar, . Identifying Active Site Cavities of Brain Derived Neurotrophic Factor Involved in Type II Diabetes. Asian Journal of Medical Sciences, (1): 8-12.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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