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Abstract
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Article Information:
Pathological Lesions in the Lungs of Neonatal Wistar Rats from Dams Administered Ethanol during Gestation
Sunday A. Musa, Shehu Ibrahim, Uduak. E. Umana, Samuel S. Adebisi and Wilson O.Hamman
Corresponding Author: Sunday A. Musa
Submitted: 2011 August, 19
Accepted: 2011 December, 20
Published: 2012 February, 25 |
Abstract:
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This study was carried out to investigate the effects of ethanol ingestion during pregnancy on the
fetal lungs development. Adult Wistar rats were used and grouped into four groups and each group having four
females and two males. Group A was the control group received only distilled water, while groups B, C and
D received 0.2 mL of 20, 25 and 30% ethanol orally respectively daily for seven days during the 4th to 10th
day of gestation. After delivery, the fetal lungs were removed and fixed in 10% buffered formalin. The
neonates’ lungs were prepared through histological techniques and stained with Haematoxylin and Eosin and
were studied under the light microscope. The result showed alveolar degeneration, bronchiole-capillary
thickening, bronchiolar degeneration and extravasations of erythrocyte in the ethanol treated groups while the
control was normal. Ethanol ingestion during pregnancy could lead to ethanol-induced lung damage in the
fetuses. Hence, alcohol ingestion should be avoided during pregnancy.
Key words: Ethanol, neonatal lungs, wistar rats, , , ,
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Abstract
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Cite this Reference:
Sunday A. Musa, Shehu Ibrahim, Uduak. E. Umana, Samuel S. Adebisi and Wilson O.Hamman, . Pathological Lesions in the Lungs of Neonatal Wistar Rats from Dams Administered Ethanol during Gestation. Asian Journal of Medical Sciences, (1): 4-7.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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