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Abstract
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Article Information:
Comparative Stabilizing Effects of Some Anticoagulants on Fasting Blood Glucose of Diabetics and Non-diabetics, Determined by Spectrophotometry (Glucose Oxidase)
Nwangwu C.O. Spencer, Josiah J. Sunday, Omage K. Erifeta, O. Georgina, Asuk A. Agbor, Uhunmwangho S. Esosa and O. Jenevieve
Corresponding Author: Omage K. Erifeta
Submitted: 2011 September, 21
Accepted: 2011 November, 16
Published: |
Abstract:
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The comparative stabilizing effects of the anticoagulants; Fluoride oxalate, EDTA and Heparin on
fasting blood glucose level were determined, using the spectrophotometry (glucose oxidase) method. Fasting
blood samples were taken from ten (10) diabetic patients and ten (10) non-diabetic people, and the blood
glucose levels determined at 30 min intervals for a maximum time of 2 h. Our results showed that the rate at
which plasma glucose changes with time varies with specific anticoagulants. With Fluoride oxalate and
Heparin, it increased by 1.77 and 6.67%, respectively, while with EDTA it decreased by 4.0%, within the first
30 minutes for non-diabetics. For diabetics, within the same period, with Fluoride oxalate and Heparin it
increased by 1.9 and 3.7%, respectively, while with EDTA it decreased by 3.6%. Blood glucose levels were
however shown to increase significantly (p<0.05) at 60 min (1 h) with the three anticoagulants in diabetics and
non-diabetics. But at 120 min (2 h) plasma glucose in Fluoride oxalate, EDTA and Heparin decreased by 16.4,
17.5 and 8.5%, respectively for non-diabetics and by 10.6, 9.8 and 8.6%, respectively for diabetics. These
showed that Fluoride oxalate had a better stabilizing effect on plasma glucose within the first 30 minutes while
Heparin is a better stabilizer at after 120 min.
Key words: Anticoagulants, EDTA, fluoride oxalate, glucose oxidase, heparin, plasma glucose,
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Cite this Reference:
Nwangwu C.O. Spencer, Josiah J. Sunday, Omage K. Erifeta, O. Georgina, Asuk A. Agbor, Uhunmwangho S. Esosa and O. Jenevieve, . Comparative Stabilizing Effects of Some Anticoagulants on Fasting Blood Glucose of Diabetics and Non-diabetics, Determined by Spectrophotometry (Glucose Oxidase). Asian Journal of Medical Sciences, (6): 234-236.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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