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2011 (Vol. 3, Issue: 5)
Article Information:

Effects of Ethanolic Leave Extract of Calotropis procera on the Histology of the Liver of Adult Male Rabbits (Oryctolagus cuniculus)

A.A. Buraimoh, T. Murdakai and J. Soni
Corresponding Author:  Buraimoh Adebayo Adekunle 

Key words:  Adult, Calotropis procera, effects, liver, male rabbits, ,
Vol. 3 , (5): 195-197
Submitted Accepted Published
2011 July, 17 2011 September, 07 2011 October, 25
Abstract:

Calotropis procera (C. procera) has been reported to be medicinal and toxic in animals. This research work was designed to evaluate the effects of ethanolic leave extract of C. procera on the liver of adult male rabbits (Oryctolagus cuniculus). Group A served as the control, which received distilled water only; Group B and Group C were treated with ethanolic extracts of C. procera at 250 and 500 mg/kg body weight respectively for two weeks(14 days) The rabbits were all humanely sacrificed on the 14th day. The liver was harvested and fixed immediately in formalin. The liver tissues were processed, stained in Haematoxylin and Eosin (H&E) and then viewed under a light microscope. Histological observations of the liver showed that ethanolic leave extract of C. procera caused damage to the liver tissues of male rabbits at a high dose as evident in necrotic tissue seen in treated groups. Therefore, caution should be taken in its usage.
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  Cite this Reference:
A.A. Buraimoh, T. Murdakai and J. Soni, 2011. Effects of Ethanolic Leave Extract of Calotropis procera on the Histology of the Liver of Adult Male Rabbits (Oryctolagus cuniculus).  Asian Journal of Medical Sciences, 3(5): 195-197.
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