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Abstract
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Article Information:
Preliminary Anti-diarrhoeal Activity of Hydromethanolic Extract of Aerial Part of Indigofera Pulchra.in Rodents
A. Mohammed, H. Ahmed, A.D.T. Goji, A.O. Okpanachi, I. Ezekiel and Y. Tanko
Corresponding Author: Mohammed Aliyu
Submitted: 2009 June, 09
Accepted: 2009 July, 11
Published: |
Abstract:
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Indigofera pulchra is used as remedies for many ailments such as in the treatment of diabetes,
prophylactic against snake-bites and as anti- inflammatory, but has not been investigated for its anti-diarrhoeal
activity. This study was therefore aimed at investigating the hydromethanolic portion of Indigofera pulchra
aerial part extract for antidiarrhoeal activity, using castor oil-induced diarrhoeal model in mice. The effect of
these extract on perfused isolated rabbit ileum were also evaluated. The hydromethanolic extract produced a
dosed dependent relaxation of the rabbit ileum. The hydromethanolic leaf extract produced a dose dependent
protection against the castor oil-induced diarrhoeal with the highest protection (80%), obtained at 500mg/kg
comparable to that of loperamide (5mg/kg), the standard agent. The preliminary phytochemical analysis
revealed that the extract contained tannins steroids, alkaloids, saponnis and flavonoids. The acute toxicity test
revealed the median lethal dose (LD50) value for the extract is greater than 5000mg/kg. The result obtained
revealed that the leaves possess pharmacological activity against diarrhoeal.
Key words: Indigofera Pulchra, antidiarrhoeal, castor oil, isolated tissue, hydromethanolic extracts, ,
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Abstract
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Cite this Reference:
A. Mohammed, H. Ahmed, A.D.T. Goji, A.O. Okpanachi, I. Ezekiel and Y. Tanko, . Preliminary Anti-diarrhoeal Activity of Hydromethanolic Extract of Aerial Part of Indigofera Pulchra.in Rodents. Asian Journal of Medical Sciences, (2): Page No: 22-25.
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ISSN (Online): 2040-8773
ISSN (Print): 2040-8765 |
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