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2011 (Vol. 3, Issue: 2)
Article Information:

Antidepressant Effects of Noni Fruit and its Active Principals

Shixin Deng and Brett J. West
Corresponding Author:  Shixin Deng 

Key words:  Active compounds, antidepressant, MAO-A & B, Morinda citrifolia, noni, ,
Vol. 3 , (2): 79-83
Submitted Accepted Published
2011 February, 24 2011 March, 26 2011 April, 20

The antidepressant effects of Morinda citrifolia (noni) fruit extracts were investigated in vitro with the Monoamine Oxidase (MAO) A and B bioassays. The ethyl acetate extract of freeze-dried noni fruit powder inhibited MAO-A and B enzymes 78 and 49%, respectively. A phytochemical study of the most active extract led to the isolation of nine compounds. Among these, three principles including two flavonoids, kaempferol and quercetin, as well as one lignan, (+)-3,4,3',4'-tetrahydro-9,7'α-epoxylignan-7α,9'-lactone, were found to be potent MAO-A and B inhibitors. These findings indicate that noni fruit is a natural MAO-A and MAO-B inhibitor, involving a synergistic effect from multiple active components.
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  Cite this Reference:
Shixin Deng and Brett J. West, 2011. Antidepressant Effects of Noni Fruit and its Active Principals.  Asian Journal of Medical Sciences, 3(2): 79-83.
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ISSN (Online):  2040-8773
ISSN (Print):   2040-8765
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