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Abstract
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Article Information:
Anti-hepatocarcinoma Effects of a Food Additive Chrysin Nanosuspension against Human HepG2 Cells
Zhi-ping Wang, Qun Zhou, Hui-zhe Shi, Sheng Xiong and Yi-fei Wang
Corresponding Author: Zhi-ping Wang
Submitted: October 10, 2014
Accepted: November 3, 2014
Published: March 15, 2015 |
Abstract:
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Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Chrysin (Chr), a major symbol ingredient in Chinese Propolis, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Chr-Nanosuspension (Chr-NS) composed of Chr and poloxamer 188 was prepared by high pressure homogenization technique. The in vitro anti-hepatocarcinoma effects of Chr-NS relative to efficacy of bulk Chr were evaluated. The particle size and zeta potential of Chr-NS were 291.1 nm and -28.7 mV, respectively. MTT assay showed that Chr-NS effectively inhibited the proliferation of HepG2 cells and the corresponding IC50 values of Chr-NS and bulk Chr were 1.55 and 3.76 &mug/mL. These results suggest that the delivery of Chr-NS is a promising approach for treating tumors.
Key words: Antitumor activity, Chrysin, Cytotoxicity, food additive, HepG2 cells, nanosuspension,
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Cite this Reference:
Zhi-ping Wang, Qun Zhou, Hui-zhe Shi, Sheng Xiong and Yi-fei Wang, . Anti-hepatocarcinoma Effects of a Food Additive Chrysin Nanosuspension against Human HepG2 Cells. Advance Journal of Food Science and Technology, (8): 627-630.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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