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Abstract
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Article Information:
Optimized Preparation of Catechin Nanoliposomes by Orthogonal Design and Stability Study
Xiaobo Luo, Rongfa Guan, Xiaoqiang Chen, Mingqi Liu, Yunbin Hao and Han Jiang
Corresponding Author: Rongfa Guan
Submitted: April 26, 2014
Accepted: May 25, 2014
Published: July 10, 2014 |
Abstract:
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Catechin nanoliposomes are prepared by reverse-phase evaporation method. Taking the entrapment efficiency of catechin nanoliposomes as the main evaluation index, the prescription of the catechin nanoliposomes was optimized by orthogonal design. Found by experiment, the orthogonal design test showed that phosphatidylcholine to cholesterol ratio had the highest influence in preparation and rotary evaporation temperature the lowest, with catechin concentration and ion strength in between. The best conditions of preparation of catechin nanoliposomes are that phosphatidylcholine to cholesterol ratio of 4, catechin concentration of 4.00 mg/mL, ion strength of 0.02 mol/Landrotary evaporation temperature of 40°C, encapsulation efficiency can reach about 53.69±1.65%, the particle size is 235±4 nm. Finally, using pH, leakage ratio and size to explore the stability, catechin nanoliposomes showed an acceptable stability.
Key words: Catechin, entrapment efficiency, nanoliposomes, orthogonal design, particle size, stability,
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Cite this Reference:
Xiaobo Luo, Rongfa Guan, Xiaoqiang Chen, Mingqi Liu, Yunbin Hao and Han Jiang, . Optimized Preparation of Catechin Nanoliposomes by Orthogonal Design and Stability Study. Advance Journal of Food Science and Technology, (7): 921-925.
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ISSN (Online): 2042-4876
ISSN (Print): 2042-4868 |
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